Current Issue : July-September Volume : 2018 Issue Number : 3 Articles : 1 Articles
The present study was aimed to investigate the antibacterial and antioxidant efficacy of chloroform, dichloromethane and methanol extracts of Sargassum wightii against the isolated human pathogens viz., Escherichia coli, Enterococcus faecalis, Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirabilis and Staphylococcus aureus. The antibacterial activity was performed by disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. The mean zones of inhibition produced by the extracts in agar diffusion assays against the tested bacterial strains were ranged from 7.3 mm to 15.00 mm. The MIC and MBC were between 12.5 ppm - 100 ppm. The maximum activity (15.00 mm) was observed in the extracts of dichloromethane against Proteus mirabilis, Enterococcus faecalis and also chloroform extract against Escherichia coli. Preliminary phytochemical analysis of Sargassum wightii showed the presence of maximum number of phytochemicals in chloroform than that of the other solvent extracts. The antioxidant activity was determined in the three extracts. Peroxidase activity was found to be higher in all three extracts. The hemolytic effect was found to be low to mild towards human erythrocytes. It is evident from the present study that this seaweed could be utilized as a good source of antibacterial and antioxidant agent in pharmaceutical industry....
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